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Fig. 2 | Cancer Cell International

Fig. 2

From: OTU deubiquitinase 4 is silenced and radiosensitizes non-small cell lung cancer cells via inhibiting DNA repair

Fig. 2

Promoter methylation is responsible for the loss of OTUD4 expression in NSCLC cells. a Schematic illustration of the arrangement of the promoter region and the region for BSP analysis. b Expression of OTUD4 mRNA in indicated cells treated with or without 5-Aza-dc. c Methylation specific PCR analysis of genomic DNA of tumor tissues from 10 patients. d Methylation status of promoter CpG islands from 3 individual clones analyzed by BSP. Error bars represent SD from 3 independent experiments. *p < 0.05. BSP, bisulfite genomic sequencing

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