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Fig. 4 | Cancer Cell International

Fig. 4

From: OTU deubiquitinase 4 is silenced and radiosensitizes non-small cell lung cancer cells via inhibiting DNA repair

Fig. 4

OTUD4 enhances cell cycle arrest and promotes cell apoptosis induced by IR. a Representative pictures of cell cycle distribution of indicated cells 12 h after irradiation. Representative images (b) and statistical quantification (c) of irradiation induced cell death analyzed by FACS. d Western blotting analysis of the expression of Caspase-3 and cleaved Caspase-3 in irradiated cells. e Western blotting analysis p-ATM, total ATM, p-CHK2, total CHK2, p53, p21 and γ-H2AX in indicated cells treated with or without irradiation. α-Tubulin and GAPDH served as loading control. Error bars represent SD from 3 independent experiments. *p < 0.05

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