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Fig. 5 | Cancer Cell International

Fig. 5

From: OTU deubiquitinase 4 is silenced and radiosensitizes non-small cell lung cancer cells via inhibiting DNA repair

Fig. 5

OTUD4 inhibits DNA damage repair. Representative pictures (a) and quantification (b) of unrepaired DSB analyzed by comet assay 3 h after irradiation. Diagram (c) and homology repair efficiency (d) determined by FACS of DR-GFP-U2OS cells transfected with indicated plasmid. Representative pictures (e) and quantification (f) of Rad51 foci in vector and OTUD4 overexpressed cells treated with IR (6 Gy) and allowed recovering for 12 h. Scale bar, 10 μm. Error bars represent SD from 3 independent experiments. *p < 0.05

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