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Fig. 3 | Cancer Cell International

Fig. 3

From: Emodin inhibits colon cancer by altering BCL-2 family proteins and cell survival pathways

Fig. 3

Effect of Emodin on the mitochondrial outer membrane potential. CoCa cells were treated with Emodin (DLD-1 ~ 18 μM; COLO 201 ~ 15 μM) for 24, 48, and 72 h. Vehicle treated cells were used as control. Mitochondrial outer membrane potential (ΔψM) was measured using JC-1 staining (a). Healthy cells with high ΔψM form JC-1 aggregates showing red fluorescence (Red ellipse), while apoptotic cells with low ΔψM exhibits green fluorescence (Green ellipse). Graphs represent the observed shift in the ΔψM of DLD-1 and COLO-201 after Emodin treatment compared to vehicle control (b). Data represents mean ± SEM from three independent experiments. Asterisks (*) p < 0.05, (**) p < 0.01 show significant change after Emodin treatment compared with the control

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