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Fig. 5 | Cancer Cell International

Fig. 5

From: Emodin inhibits colon cancer by altering BCL-2 family proteins and cell survival pathways

Fig. 5

Emodin modulates growth and proliferation signaling pathways to promote apoptosis in colon cancer cells. Heatmap showing Emodin induced changes in cell survival related proteins was generated using apoptosis antibody microarray data (a). Each cell in the heatmap represents the fold change in protein expression in Emodin-treated CoCa cells compared to vehicle-treated control. Red represents increase while green represents decrease in protein expression, and intensity of color depends on level of expression. e Effect of Emodin treatment (DLD-1 ~ 18 μM; COLO 201 ~ 15 μM; 36 and 48h) on expression of key signaling molecules of PI3K/AKT, MAPK/ERK, NF-κβ and Jak/STAT pathways compared to vehicle control is shown by western blot (be). β-actin was used as the loading control. The quantitative bar graphs shown represent ratio of protein in Emodin treated versus vehicle-treated after normalization with β-actin band intensity. ‘BD’ represents below detection. All graphs represent the mean fold change intensity value ± SEM from three independent experiments; Asterisks (*) p < 0.05, (**) p < 0.01, (***) p < 0.001 show significant change after Emodin treatment compared with the control

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