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Table 2 Cox model analysis for the correlation between Nectin-4 expression level and patients’ clinical parameters

From: Over-expression of Nectin-4 promotes progression of esophageal cancer and correlates with poor prognosis of the patients

Clinical parameters Uni-variate Multi-variate
HR (95% CI) P HR (95% CI) P
Gender (M/F) 2.618 (1.285–5.337) 0.008 1.827 (0.765–4.364) 0.175
Age (years) (≥ 60/< 60) 1.093 (0.630–1.894) 0.752 1.543 (0.828–2.878) 0.172
Tumor size (≥ 4.5 cm/< 4.5 cm) 1.674 (1.014–2.763) 0.044 1.363 (0.792–2.346) 0.264
Pathological stage (III–IV/I–II) 0.805 (0.436–1.485) 0.487 0.723 (0.377–1.385) 0.328
Tumor stage (T3–T4/T1–T2) 2.950 (0.923–7.127) 0.008 1.613 (0.898–5.021) 0.087
Lymph node metastasis (yes/no) 2.518 (1.290–3.609) 0.003 1.689 (0.928–3.074) 0.086
Nectin-4 expression (high/low) 1.704 (1.027–2.825) 0.039 1.795 (1.042–3.092) 0.035