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Table 2 Cox model analysis for the correlation between Nectin-4 expression level and patients’ clinical parameters

From: Over-expression of Nectin-4 promotes progression of esophageal cancer and correlates with poor prognosis of the patients

Clinical parameters

Uni-variate

Multi-variate

HR (95% CI)

P

HR (95% CI)

P

Gender (M/F)

2.618 (1.285–5.337)

0.008

1.827 (0.765–4.364)

0.175

Age (years) (≥ 60/< 60)

1.093 (0.630–1.894)

0.752

1.543 (0.828–2.878)

0.172

Tumor size (≥ 4.5 cm/< 4.5 cm)

1.674 (1.014–2.763)

0.044

1.363 (0.792–2.346)

0.264

Pathological stage (III–IV/I–II)

0.805 (0.436–1.485)

0.487

0.723 (0.377–1.385)

0.328

Tumor stage (T3–T4/T1–T2)

2.950 (0.923–7.127)

0.008

1.613 (0.898–5.021)

0.087

Lymph node metastasis (yes/no)

2.518 (1.290–3.609)

0.003

1.689 (0.928–3.074)

0.086

Nectin-4 expression (high/low)

1.704 (1.027–2.825)

0.039

1.795 (1.042–3.092)

0.035