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Table 2 Genotype frequencies of TNFAIP8 gene polymorphism among patients and controls and their associations with the susceptibility of endometrial cancer

From: Association of TNFAIP8 gene polymorphisms with endometrial cancer in northern Chinese women

Variables

Cases (%) n = 226

Controls (%) n = 248

P a

Crude OR (95% CI)

P

Adjust OR (95% CI)

P b

Genotypes

 rs11064

  

0.029

    

  AA

138 (61.1)

178 (71.8)

     

  AG

70 (31.0)

60 (24.2)

 

1.505 (0.998–2.268)

0.051

1.571 (0.972–2.539)

0.065

  GG

18 (7.9)

10 (4.0)

 

2.322 (1.039–5.190)

0.040

2.582 (1.034–6.445)

0.042

  AG + GG

88 (38.9)

70 (28.2)

 

1.622 (1.104–2.382)

0.014

1.778 (1.134–2.782)

0.012

 rs1045241

  

0.529

    

  CC

143 (63.3)

167 (67.3)

     

  CT

71 (31.4)

72 (29.1)

 

1.152 (0.775–1.712)

0.485

1.144 (0.906–2.299)

0.122

  TT

12 (5.3)

9 (3.6)

 

1.557 (0.638–3.802)

0.331

1.980 (0.699–5.607)

0.198

  CT + TT

83 (36.7)

81 (32.7)

 

1.197 (0.819–1.748)

0.353

1.501 (0.961–2.344)

0.074

 rs1045242

  

0.197

    

  AA

144 (63.7)

177 (71.4)

     

  AG

74 (32.7)

65 (26.2)

 

1.399 (0.939–2.086)

0.099

1.568 (0.980–2.507)

0.061

  GG

8 (3.6)

6 (2.4)

 

1.639 (0.556–4.831)

0.370

2.695 (0.799–9.084)

0.110

  AG + GG

82 (36.3)

71 (28.6)

 

1.420 (0.965–2.089)

0.076

1.651 (1.049–2.599)

0.030

Alleles

 rs11064

  A

346 (76.5)

416 (83.9)

     

  G

106 (23.5)

80 (16.1)

0.005

1.593 (1.153–2.201)

0.005

1.719 (1.180–2.506)

0.005

 rs1045241

  C

357 (79.0)

406 (81.9)

     

  T

95 (21.0)

90 (18.1)

0.265

1.200 (0.870–1.656)

0.265

1.457 (1.001–2.120)

0.050

 rs1045242

  A

362 (80.1)

419 (84.5)

     

  G

90 (19.9)

77(15.5)

0.077

1.353 (0.968–1.892)

0.077

1.636 (1.107–2.417)

0.014

  1. BMI body mass index, OR odds ratio, CI confidence interval
  2. aTwo-sided Chi-squared test
  3. bData were calculated by logistic regression, adjusted for age, smoking history, BIM, menopausal status