Skip to main content

Advertisement

Fig. 2 | Cancer Cell International

Fig. 2

From: Histone variant MacroH2A1 is downregulated in prostate cancer and influences malignant cell phenotype

Fig. 2

Association of MacroH2A1.1 and QKI transcript levels with clinicopathological parameters and diagnostic performance. a Distribution of MacroH2A1.1 and QKI transcript levels in PCa cases, determined by RT-qPCR and normalized with GUSB mRNA levels, according to categorized < 7 (n = 68) and ≥ 7 (n = 129) Gleason score; Mann–Whitney U test: **p < 0.01, ****p < 0.0001. b ROC curves showing biomarker performance evaluation of MacroH2A1.1 (AUC = 0.92, 95% CI 0.876–0.965, p < 0.0001), DDX17 (AUC = 0.93, 95% CI 0.872–0.980, p < 0.0001), and QKI (AUC = 0.94, 95% CI 0.897–0.987, p < 0.0001) transcript levels as discriminators of prostate cancer (PCa, n = 195) from morphological normal prostate tissue (MNPT, n = 15). AUC area under curve, CI confidence interval

Back to article page