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Table 2 Validity estimates for MacroH2A1.1 and QKI expression levels as diagnostic biomarkers for prostate cancer identification

From: Histone variant MacroH2A1 is downregulated in prostate cancer and influences malignant cell phenotype

Parameter MacroH2A1.1 performance DDX5 performance DDX17 performance QKI performance
Sensitivity (%) 80.7 82.7 47.3 88.8
Specificity (%) 93.3 93.3 93.3 93.3
Accuracy (%) 81.6 83.5 50.5 88.7
Positive likelihood ratio (LR+) 12.04 12.34 7.06 13.25
Negative likelihood ratio (LR−) 0.21 0.19 0.56 0.12
AUC (95% IC) p value 0.92 (0.876–0.965) p < 0.0001 0.65 (0.549–0.751) p = 0.0533 0.93 (0.872–0.980) p < 0.0001 0.94 (0.897–0.987) p < 0.0001