Table 2 Validity estimates for MacroH2A1.1 and QKI expression levels as diagnostic biomarkers for prostate cancer identification
Parameter | MacroH2A1.1 performance | DDX5 performance | DDX17 performance | QKI performance |
|---|---|---|---|---|
Sensitivity (%) | 80.7 | 82.7 | 47.3 | 88.8 |
Specificity (%) | 93.3 | 93.3 | 93.3 | 93.3 |
Accuracy (%) | 81.6 | 83.5 | 50.5 | 88.7 |
Positive likelihood ratio (LR+) | 12.04 | 12.34 | 7.06 | 13.25 |
Negative likelihood ratio (LR−) | 0.21 | 0.19 | 0.56 | 0.12 |
AUC (95% IC) p value | 0.92 (0.876–0.965) p < 0.0001 | 0.65 (0.549–0.751) p = 0.0533 | 0.93 (0.872–0.980) p < 0.0001 | 0.94 (0.897–0.987) p < 0.0001 |