Fig. 6
From: Targeting Akt by SC66 triggers GSK-3β mediated apoptosis in colon cancer therapy
SC66 exhibited the anti-tumor effects in vivo. Nude mice were injected s.c. with 1 × 106 HCT-116. Once the tumor was measurable, mice were treated daily with SC66 at 25 mg/kg by i.p. injection every other 3 days for 15 days. a Representative tumors at the end of the experiment. (the most significant group of three). b, c Tumor weight (b) and tumor volume at (c) indicated time points after treatment was calculated (n = 3 per group). Statistical significance is indicated for the comparison of SC66-treated tumor. Data represent the mean ± SEM of four independent experiments. ***P < 0.001 vs. WT. d The levels of P-Akt, total-Akt, P-GSK-3β, total-GSK-3β and Bcl-xL were analyzed in representative tumors by Western blotting analysis. Similar results were obtained from three independent experiments. e Schematic representation of SC66 induced apoptotic pathway