Skip to main content
Fig. 5 | Cancer Cell International

Fig. 5

From: HOXA11-AS promotes the progression of oral squamous cell carcinoma by targeting the miR-518a-3p/PDK1 axis

Fig. 5

HOXA11-AS increases PDK1 expression by inhibiting miR-518a-3p. a Bioinformatics analysis showed the predicted binding site between PDK1 and miR-518a-3p. b Luciferase activity was detected in HEK293T cells co-transfected with miR-518a-3p mimics and luciferase reporters containing PDK1 or mutant form. c The expression of PDK1 in OSCC tissues or adjacent normal tissues was measured by immunohistochemistry (IHC) assay. d, e The expression of PDK1 mRNA and protein in indicated groups were detected in SCC-25 cells by using qRT-PCR and western blotting. f, g The expression of PDK1 protein in indicated groups were detected in SCC-25 cells by using qRT-PCR and western blotting. h Positive correlation between HOXA11-AS and PDK1 expression in OSCC tissues. i Negative correlation between PDK1 and miR-518a-3p in OSCC tissues. (#P < 0.05, **P < 0.01)

Back to article page

Cancer Cell International

ISSN: 1475-2867

Contact us