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Table 2 Stratified analyses of AXIN2 148 C/T, 1365 C/T, and rs4791171 A/G variants on overall cancer risk

From: New insights into the association between AXIN2 148 C/T, 1365 C/T, and rs4791171 A/G variants and cancer risk

Variables

N

Case/control

OR (95% CI)

P h

P

OR (95% CI)

P h

P

OR (95% CI)

P h

P

OR (95% CI)

P h

P

M-allele vs. W-allele

MM vs. WW

MW vs. WW

MM+MW vs. WW

148 C/T

 Total

15

2909/2907

0.88 (0.77–0.99)

0.004

0.041

0.82 (0.63–1.06)

0.007

0.132

0.84 (0.75–0.95)

0.112

0.004

0.82 (0.69–0.96)

0.022

0.015

 Ethnicity

  Asian

10

2209/2226

0.85 (0.73–0.98)

0.016

0.027

0.76 (0.57–1.03)

0.040

0.078

0.84 (0.74–0.96)

0.074

0.009

0.80 (0.66–0.96)

0.030

0.020

  Caucasian

4

512/582

0.85 (0.72–1.01)

0.380

0.061

0.75 (0.53–1.07)

0.304

0.108

0.77 (0.58–1.00)

0.896

0.053

0.76 (0.59–0.98)

0.701

0.036

  Latin

1

188/99

1.48 (1.05–2.09)

–

0.026

2.64 (1.21–5.78)

–

0.015

1.63 (0.84–3.13)

–

0.146

1.86 (0.99–3.51)

–

0.054

 Cancer type

  LC

4

1061/1047

0.74 (0.65–0.84)

0.602

< 0.001

0.53 (0.40–0.70)

0.360

< 0.001

0.76 (0.63–0.92)

0.865

0.005

0.70 (0.59–0.84)

0.803

< 0.001

  CRC

3

411/387

1.10 (0.90–1.35)

0.071

0.348

1.36 (0.87–2.11)

0.096

0.178

0.96 (0.68–1.34)

0.123

0.796

1.01 (0.74–1.39)

0.060

0.932

  PC

2

187/200

0.83 (0.62–1.12)

0.099

0.223

1.00 (0.54–1.87)

0.509

0.987

0.54 (0.35–0.84)

0.088

0.006

0.62 (0.41–0.93)

0.078

0.022

  Others

7

1250/1273

0.98 (0.87–1.11)

0.217

0.751

0.98 (0.76–1.26)

0.363

0.862

0.96 (0.80–1.15)

0.375

0.640

0.96 (0.81–1.14)

0.218

0.664

 Source

  HB

8

1684/1748

0.94 (0.85–1.04)

0.093

0.219

0.89 (0.72–1.09)

0.128

0.267

0.93 (0.80–1.09)

0.564

0.364

0.92 (0.80–1.07)

0.268

0.272

  PB

7

1225/1159

0.82 (0.65–1.02)

0.009

0.074

0.73 (0.44–1.22)

0.007

0.235

0.74 (0.62–0.88)

0.083

0.001

0.74 (0.56–0.97)

0.037

0.032

1365 C/T

 Total

4

587/605

0.71 (0.61–0.98)

0.873

0.038

1.11 (0.34–3.70)

–

0.859

0.63 (0.44–0.91)

0.668

0.014

0.66 (0.47–0.94)

0.775

0.021

 Ethnicity

  Asian

1

303/305

0.66 (0.43–0.99)

–

0.043

1.11 (0.34–3.70)

–

0.859

0.53 (0.32–0.86)

–

0.010

0.58 (0.37–0.92)

–

0.020

  Caucasian

3

284/300

0.81 (0.47–1.38)

0.855

0.440

NA

  

0.80 (0.46–1.39)

0.846

0.428

0.80 (0.46–1.39)

0.846

0.428

 Cancer type

  LC

2

403/405

0.67 (0.46–0.97)

0.806

0.034

1.11 (0.34–3.70)

–

0.859

0.57 (0.37–0.87)

0.548

0.009

0.61 (0.41–0.91)

0.669

0.016

  PC

1

84/100

1.04 (0.37–2.94)

–

0.936

NA

  

1.05 (0.36–3.01)

–

0.934

1.05 (0.36–3.01)

–

0.934

  AT

1

100/100

0.74 (0.30–1.79)

–

0.503

NA

  

0.73 (0.29–1.81)

–

0.490

0.73 (0.29–1.81)

–

0.490

rs4791171 A/G

 Total

3

785/443

0.99 (0.85–1.17)

0.786

0.864

0.94 (0.66–1.33)

0.873

0.728

0.86 (0.62–1.17)

0.522

0.322

0.89 (0.66–1.19)

0.575

0.429

 Ethnicity

  Asian

1

564/250

1.00 (0.80–1.24)

–

0.997

0.93 (0.69–1.48)

–

0.773

0.84 (0.63–1.31)

–

0.434

0.88 (0.68–1.34)

–

0.556

  Arabian

2

221/193

0.96 (0.73–1.27)

0.511

0.778

0.96 (0.66–1.62)

0.603

0.843

0.87 (0.56–1.36)

0.257

0.538

0.89 (0.69–1.36)

0.294

0.596

 Cancer type

  BC

1

99/83

0.87 (0.57–1.31)

–

0.497

0.80 (0.35–1.84)

–

0.599

0.65 (0.33–1.28)

–

0.209

0.69 (0.36–1.31)

–

0.255

  GBC

1

564/250

1.00 (0.80–1.24)

–

0.997

0.93 (0.59–1.48)

–

0.773

0.84 (0.53–1.31)

–

0.434

0.88 (0.58–1.34)

–

0.556

  CRC

1

122/110

1.04 (0.72–1.51)

–

0.822

1.07 (0.53–2.17)

–

0.854

1.09 (0.60–1.96)

–

0.778

1.08 (0.63–1.87)

–

0.777

  1. AT astrocytoma, BC breast cancer, CRC colorectal cancer, HB hospital-based, PB population-based, NA not available, LC lung adenocarcinoma, PC prostate adenocarcinoma, GBC gallbladder cancer
  2. aP value of Q-test for heterogeneity test (Pheter)
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Cancer Cell International

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