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Fig. 5 | Cancer Cell International

Fig. 5

From: The histone H3 lysine-27 demethylase UTX plays a critical role in colorectal cancer cell proliferation

Fig. 5

UTX regulates ATK activation by regulating KIF14 in HCT116 and SW620 cells in vitro. a Correlation between UTX and KIF14 levels in CRC patients (nā€‰=ā€‰135). Each point represents one independent sample, and the correlation coefficient (R) and p value are presented. b Western blotting analysis of UTX, KIF14, pAKT (S473, T308) and other indicated proteins in HCT116 and SW620 cells. c Representative photographs of UTX and KIF14 IHC staining in the indicated tumours. All the experiments were performed at least three times. d CCK8 assays was used to detected proliferation of HCT116 cells after transfection with shCtrl, shUTX lentivirus and shUTX lentivirus plus KIF14 overexpression lentivirus

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