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Fig. 3 | Cancer Cell International

Fig. 3

From: Low expression of SPARC in gastric cancer-associated fibroblasts leads to stemness transformation and 5-fluorouracil resistance in gastric cancer

Fig. 3

Effect of GCAF-derived SPARC on 5-FU-induced apoptosis and stemness transformation in gastric cancer. a Flow cytometric apoptosis analysis. b Comparison of the proportion of apoptotic SGC-7901 cells after treatment with CM from GCAFs. c Comparison of the proportion of apoptotic MKN-45 cells after treatment with CM from GCAFs. d Expression levels of mitochondrial pathway apoptosis-associated proteins in gastric cancer cells after treatment with 5-FU for 72 h. e Flow cytometric analysis of stemness biomarkers. f Comparison of the CD44+/CD24− cell population in GCAF-sh cells and the GCAF-nc cells. **P < 0.01

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Cancer Cell International

ISSN: 1475-2867

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