Table 3 Univariate and multivariable Cox regression analyses for independence assessment of prognostic signature
n | Univariate analysis | Multivariate analysis | ||||||
|---|---|---|---|---|---|---|---|---|
HR | 95% CI | P-value | Coefficient | HR | 95% CI | P-value | ||
Model group (n = 265) | ||||||||
Age (high/low) | 265 | 0.946 | 0.636–1.408 | 0.784 | 0.522 | 1.686 | 1.103–2.577 | 0.016 |
Gender (male/female) | 265 | 1.872 | 1.173–2.988 | 0.009 | 0.463 | 1.589 | 0.992–2.547 | 0.054 |
AJCC PT (T4, T3/T2, T1) | 265 | 1.385 | 0.876–2.191 | 0.164 | − 0.084 | 0.919 | 0.546–1.547 | 0.752 |
AJCC PN (yes/N0) | 265 | 1.639 | 1.034–2.599 | 0.036 | 0.121 | 1.128 | 0.596–2.135 | 0.711 |
AJCC PM (yes/M0) | 265 | 1.056 | 0.512–2.178 | 0.883 | 0.208 | 1.231 | 0.574–2.637 | 0.594 |
AJCC stage (IV, III/II, I) | 265 | 1.607 | 1.072–2.409 | 0.022 | 0.234 | 1.264 | 0.690–2.314 | 0.448 |
Prognostic signature (high/low) | 265 | 7.355 | 4.378–12.356 | < 0.001 | 2.098 | 8.148 | 4.718–14.071 | < 0.001 |
Validation group (n = 300) | ||||||||
Age (high/low) | 300 | 1.356 | 0.995–1.849 | 0.054 | 0.400 | 1.491 | 1.090–2.041 | 0.012 |
Gender (male/female) | 300 | 0.997 | 0.719–1.383 | 0.986 | 0.134 | 1.144 | 0.818–1.599 | 0.432 |
AJCC PT (T4, T3/T2, T1) | 300 | 2.200 | 1.613–3.000 | < 0.001 | 0.122 | 1.130 | 0.776–1.647 | 0.523 |
AJCC PN (N2, N1/N0) | 300 | 3.023 | 1.542–5.927 | < 0.001 | 0.378 | 1.459 | 0.712–2.987 | 0.302 |
AJCC PM (MX, M1/M0) | 300 | 3.553 | 2.305–5.478 | < 0.001 | 0.410 | 1.507 | 0.950–2.392 | 0.081 |
AJCC stage (IV, III/II, I) | 300 | 3.410 | 2.366–4.915 | < 0.001 | 0.977 | 2.655 | 1.652–4.267 | 0.000 |
Prognostic signature (high/low) | 300 | 3.919 | 2.817–5.453 | < 0.001 | 1.236 | 3.443 | 2.435–4.866 | < 0.001 |