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Table 3 Univariate and multivariable Cox regression analyses for independence assessment of prognostic signature

From: Integrated analysis reveals potential long non-coding RNA biomarkers and their potential biological functions for disease free survival in gastric cancer patients

  n Univariate analysis Multivariate analysis
HR 95% CI P-value Coefficient HR 95% CI P-value
Model group (n = 265)
Age (high/low) 265 0.946 0.636–1.408 0.784 0.522 1.686 1.103–2.577 0.016
Gender (male/female) 265 1.872 1.173–2.988 0.009 0.463 1.589 0.992–2.547 0.054
AJCC PT (T4, T3/T2, T1) 265 1.385 0.876–2.191 0.164 − 0.084 0.919 0.546–1.547 0.752
AJCC PN (yes/N0) 265 1.639 1.034–2.599 0.036 0.121 1.128 0.596–2.135 0.711
AJCC PM (yes/M0) 265 1.056 0.512–2.178 0.883 0.208 1.231 0.574–2.637 0.594
AJCC stage (IV, III/II, I) 265 1.607 1.072–2.409 0.022 0.234 1.264 0.690–2.314 0.448
Prognostic signature (high/low) 265 7.355 4.378–12.356 < 0.001 2.098 8.148 4.718–14.071 < 0.001
Validation group (n = 300)
Age (high/low) 300 1.356 0.995–1.849 0.054 0.400 1.491 1.090–2.041 0.012
Gender (male/female) 300 0.997 0.719–1.383 0.986 0.134 1.144 0.818–1.599 0.432
AJCC PT (T4, T3/T2, T1) 300 2.200 1.613–3.000 < 0.001 0.122 1.130 0.776–1.647 0.523
AJCC PN (N2, N1/N0) 300 3.023 1.542–5.927 < 0.001 0.378 1.459 0.712–2.987 0.302
AJCC PM (MX, M1/M0) 300 3.553 2.305–5.478 < 0.001 0.410 1.507 0.950–2.392 0.081
AJCC stage (IV, III/II, I) 300 3.410 2.366–4.915 < 0.001 0.977 2.655 1.652–4.267 0.000
Prognostic signature (high/low) 300 3.919 2.817–5.453 < 0.001 1.236 3.443 2.435–4.866 < 0.001
  1. The median of prognostic signature scores was used as the cut-off value to stratify gastric cancer patients into high risk group and low risk group
  2. AJCC, the American Joint Committee on Cancer; HR, hazard ratio; CI, confidence interval