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Fig. 5 | Cancer Cell International

Fig. 5

From: UBN2 promotes tumor progression via the Ras/MAPK pathway and predicts poor prognosis in colorectal cancer

Fig. 5

UBN2 inhibition suppresses CRC Proliferation and Metastasis via the Ras/MAPK Signaling Pathway. a The expression of UBN2, KRAS, Rac1/2/3, total ERK, phosphorylated ERK, cyclinD1, p21 and p27 in vector-infected (NC) and UBN2 siRNA-infected (UBN2-S1, UBN2-S2) CRC cell lines were detected by Western blotting. b Real-time RT-PCR analyses of cyclinD1, p21, and p27 were performed in the indicated CRC cell lines. Error bars represent mean ± SD from 3 independent experiments. c A model for UBN2 regulation of tumorigenesis. *p < 0.05, **p < 0.01

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