Fig. 4
From: Decreased SATB1 expression promotes AML cell proliferation through NF-κB activation
SATB1 regulated AML cell growth via the activation of NF-κB signaling pathway. Gene expression was compared between SATB1-shRNA1 cells and HL-60 CTR cells and the results were analyzed by KEGG Pathway. a The hot map showed 862 downregulated and 377 upregulated genes in SATB1-shRNA cells. b Protein levels of p38 MAPK, phospho-p38 MAPK, Akt, phospho-Akt and total NF-κB p65 in both SATB1-shRNA and CTR cells were assessed by western blotting. c, d Results showed that total and nuclear NF-κB p65 levels were significantly increased in SATB1-shRNA cells, while cytoplasm protein levels showed no difference (P < 0.0001)