Skip to main content
Fig. 12 | Cancer Cell International

Fig. 12

From: Overexpression of mircoRNA-137 inhibits cervical cancer cell invasion, migration and epithelial–mesenchymal transition by suppressing the TGF-β/smad pathway via binding to GREM1

Fig. 12

Schematic representation of the underlying mechanism of miR-137 in CC. In CC, the expression of miR-137 decreased significantly and the expression of GREM1 increased significantly. MiR-137 can target and inhibit the expression of GREM1 gene. Inhibition of miR-137 could promote the expression of GREM1, and GREM1 could promote the expression of TGF-β1, Smad2, Smad3, N-cadherin and Vimentin. Overexpression of miR-137 could inhibit the CC cell proliferation, migration and EMT while inducing apoptosis. CC cervical cancer, GREM1 gremlin-1, miR-137 microRNA-137

Back to article page

Cancer Cell International

ISSN: 1475-2867

Contact us