Skip to main content
Fig. 6 | Cancer Cell International

Fig. 6

From: Overexpression of mircoRNA-137 inhibits cervical cancer cell invasion, migration and epithelial–mesenchymal transition by suppressing the TGF-β/smad pathway via binding to GREM1

Fig. 6

Overexpression of miR-137 inhibits EMT and the activation of TGF-β/smad pathway by binding to GREM1 in CC. a The miR-137 expression and the mRNA expression of GREM1, TGF-β1, Smad2, Smad3 and Smad4 in CC cells treated with miR-137 mimic, inhibitor and/or siRNA-GREM1 examined by RT-qPCR normalized to cells without transfection; b, c the protein expression and protein bands of GREM1, TGF-β1, Smad2, Smad3, Smad4, E-cadherin N-cadherin and Vimentin in cells treated with miR-137 mimic, miR-137 inhibitor and/or siRNA-GREM1, normalized to β-actin; *p < 0.05 vs. the blank and NC group; statistical data were presented as mean ± standard deviation; one-way analysis of variance was used for multi-group comparisons; the experiment was repeated 3 times independently. EMT epithelial–mesenchymal transition, CC cervical cancer, GREM1 gremlin-1, miR-137 microRNA-137, TGF-β1 transforming growth factor β1, NC negative control

Back to article page