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Table 2 Subgroup analysis of PD-L1 and OS, PFS in cervical cancer

From: Elevated PD-L1 expression predicts poor survival outcomes in patients with cervical cancer

Factors

No. of studies

Effects model

HR (95% CI)

p

Heterogeneity

I2(%) Ph

OS

 Total

7

Random

2.52 (1.09–5.83)

0.031

73

0.001

Ethnicity

 Asian

5

Fixed

4.77 (3.02–7.54)

< 0.001

18

0.3

 Caucasian

2

Fixed

1.13 (0.68–1.88)

0.634

0

0.562

Sample size

 < 100

3

Fixed

5.01 (1.93–13.03)

0.001

0

0.471

 ≥ 100

4

Random

1.75 (0.55–5.59)

0.344

83.7

< 0.001

Treatment

 Surgery

5

Fixed

3.04 (1.42–6.48)

0.004

36.6

0.177

 Non-surgery

2

Random

2.29 (0.51–10.34)

0.28

93.6

< 0.001

PFS

 Total

3

Random

2.07 (0.52–8.23)

0.302

77.3

0.012

Ethnicity

 Asian

2

Fixed

4.78 (1.77–12.91)

0.002

28.7

0.236

 Caucasian

1

NA

1.02 (0.62–1.69)

0.939

NA

NA

  1. OS, overall survival; PFS, progression-free survival; NA, not available