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Fig. 3 | Cancer Cell International

Fig. 3

From: The ionophore antibiotic gramicidin A inhibits pancreatic cancer stem cells associated with CD47 down-regulation

Fig. 3

In vitro cytotoxic effects of GrA and Sal on BxPC-3 and MIA PaCa-2 cells. a Viability of cultured BxPC-3 and MIA PaCa-2 cells treated with appropriate concentrations of GrA or Sal for 48 h by CCK-8 assay. Data of each concentration were from 3 replicated wells. b Flow cytometry results detecting apoptosis in BxPC-3 and MIA PaCa-2 cells were shown. Cells were treated with 0.1 μM GrA or Sal for 24 h. c SEM images presenting surface morphological changes of BxPC-3 and MIA PaCa-2 cells treated with 0.05 μM GrA or Sal, on which the red arrow indicates microvilli-like protrusions on cell membrane surface. Scale bar: 5 μm (left), 500 nm (right)

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Cancer Cell International

ISSN: 1475-2867

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