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Table 1 Main characteristics of included studies about PD-L1 in this meta-analysis

From: The prognostic significance of PD-L1 and PD-1 expression in patients with nasopharyngeal carcinoma: a systematic review and meta-analysis

Author Year Origin Range of year Categories No. of patients Cut off value for PD-L1 positive No. of positive Detected area Endpoints Detection method Hazard ratio Calculation of HRs Quality score
Cao et al. 2018 China NA Primary 108 H-score > 140 18 TC OS, PFS FFPE, IHC K–M curve Univariate 7
Chan et al. 2017 Hong Kong 2005–2009 primary 161 ≥ 1%, ≥ 5% 122, 38 TC or IC OS, PFS FFPE, IHC Report Univariate and multivariate 7
Chang et al. 2017 Philippines 2008–2011 NA 56 ≥ 1%, ≥ 5% 36, 30 TC OS FFPE, IHC Report Univariate 7
Fang et al. 2014 China 2004–2008 Primary 139 H-score > 35 62 TC and mesenchymal cells DFS FFPE, IHC Report Univariate 8
Larbcharoensub et al. 2018 Thailand 2007–2012 Primary 114 ≥ 5% 81 TC or IC OS FFPE, IHC K–M curve Univariate 8
Lee et al. 2016 Hong Kong 2005–2009 Primary 104 > 25% 22 TC OS, PFS, DMFS FFPE, IHC Report Univariate and multivariate 9
Li et al. 2017 China 2009–2015 Primary 120 H-score ≥ 5 54 TC OS, DFS FFPE, IHC K–M curve Univariate 6
Liu et al. 2018 China NA NA 208 ≥ 4% (TC), ≥ 2% (IC) 107 (TC), 131 (IC) TC, IC, TC and IC OS, DFS FFPE, IHC Report Univariate and multivariate 7
Ono et al. 2018 Japan 2000–2015 Primary 66 ≥ 5% 53 (TC), 50 (IC) TC, IC OS PFS FFPE, IHC Report Univariate and multivariate 8
Qu et al. 2018 China NA NA 96 > 10% 28 TC DMFS FFPE, IHC K–M curve Univariate 7
Zhang et al. 2015 China NA NA 139 H-score > 35 58 Tumor tissue DFS FFPE, IHC K–M curve Univariate 7
Zheng et al. 2017 China 2010–2012 Primary 85 Score ≥ 3 29 TC OS, DMFS FFPE, IHC Report Multivariate 7
Zhou et al. 2017 China 2001–2013 Recurrence 132 H-score > 190 88 TC OS FFPE, IHC Report Multivariate 9
Zhou et al. [2] 2017 China 2010–2012 Primary 99 H-score ≥ 155 61 TC OS FFPE, IHC Report Multivariate 9
Zhu et al. 2017 China 1991–2000 Primary 209 ≥ 5% 68 (TC), 98 (IC) TC, IC OS, DFS FFPE, IHC Report Univariate and multivariate 8
  1. DFS: disease-free survival; DMFS: distant metastasis-free survival; FFPE: Formalin-Fixed and Paraffin-Embedded; HRs: hazard ratios; IC: immune cells; IHC: immunohistochemistry; K–M curve: Kaplan–Meier curve; NA: not available; No: number; OS: overall survival; PFS: progression-free survival; TC: tumor cells