From: The role of fibromodulin in cancer pathogenesis: implications for diagnosis and therapy
Cancer type | Model | Expression | Function/signaling pathway | Ref |
---|---|---|---|---|
CLL | Human | Up regulation | Expansion of specific CD8 autologous T lymphocytes | [23] |
Human | Up regulation | Collagen fibrillogenesis and cell adhesion and contribute to modulation of cytokine activity, suppression of tumor growth, and prevention of apoptosis | [24] | |
Human | Up regulation | Binds TGF-β and typically negatively modulates its activity overexpression in CLL | [25] | |
Human | Up regulation | modulation of TGF-β signaling and cell adhesion | [26] | |
Human | Up regulation | Among the four patients with increase of CTL was observed after the fourth and sixth dendritic cell vaccination | [27] | |
Human | Up regulation | Tumor progression | [28] | |
Human | Up regulation | Tumor progression | [29] | |
Human | Up regulation | Activation of normal B and T lymphocytes, tonsil B cells, CLL B cells, and B-CLL cell lines | [30] | |
GBM | Cell line | Up regulation | Induce migration, promoter methylation and transcript, actin cytoskeleton remodeling/FAK-Src-Rho-ROCK signaling | [31] |
Human | Up regulation | Generation of neoplastic ECM and induce tumor progression and invasion | [32] | |
Human | Up regulation | The methylation of FMOD promoter is correlated with good prognosis | [33] | |
Prostate cancer | Cell line | Up regulation | Modulate the activity of transcription factors, suppression of tumor growth and apoptosis prevention | [34] |
Human | Up regulation | Regulation of angiogenesis, reprogramming of human fibroblasts into pluripotent cells, modulation of TGF-β activity, inflammatory processes and association with metastatic phenotypes | [9] | |
Colon cancer | Mouse | Down regulation | modulation of collagen fibrils in tumor stroma | [35] |
Cell line | Up regulation | Increasing of ECM density that inhibit the migration and invasion/collagen types I, III, IV and V, biglycan | [36] | |
Mice | Up regulation | Prompt the formation of a dense stroma and an elevated interstitial fluid pressure | [37] | |
Leiomyoma | Human | Up regulation | Connective tissue remodeling, specifically fibrillogenesis, cell–cell adhesion and modulation of cytokine autocrine/paracrine actions | [17] |
Human tumor | Up regulation | transfection of the cells with Smad3 SiRNA resulted in significant reduction in TGF-β-induced FMOD TGF-β, through Smad and MAPK signalling pathways, regulated the expression of FMOD | [17] | |
Myometrium | Human | Up regulation | FMOD regulated by gonadotropin-releasing hormone analogue therapy and TGF-β through Smad and MAPK-mediated signaling. Connective tissue remodeling, specifically fibrillogenesis, cell–cell adhesion and modulation of cytokine autocrine/paracrine actions | [17] |
SCLC | Cell line | Down regulation | Inhibit proliferation, migration, and invasion, angiogenesis/VEGF, TGF-β1, FGF-2, and PDGF-B | [38] |
MCL | Human | Up regulation | Activation of normal B and T lymphocytes, tonsil B cells | [30] |
Myxoma | Human | Up regulation | Diagnostic usefulness | [39] |
Insulinoma | Mice | Up regulation | Inhibition of expression by anti-inflammatory agents showed that FMOD promoted the formation of a dense stroma and an elevated interstitial fluid pressure | [37] |
Thyroid cancer | Mice | Up regulation | Inhibition of expression by anti-inflammatory agents showed that FMOD promoted the formation of a dense stroma and an elevated interstitial fluid pressure | [37] |