Table 2 FMOD gene therapy in cancer
From: The role of fibromodulin in cancer pathogenesis: implications for diagnosis and therapy
Cancer type | Model | Strategy | Function(s) | Citation |
|---|---|---|---|---|
CLL | Cell line | Using siRNA against FMOD | Induce apoptosis, cells aggregated together and appeared to be granular | [40] |
Breast cancer | Cell line | Using recombinant Adenovirus FMOD | Suppresses NF-κB DNA binding and TGF-β1 that control of cell proliferation and oncogenesis | [21] |
Leukemia | Cell line | Using siRNA against FMOD | Diminished the apoptosis of B-CLL cells | [62] |
Glioblastoma | Cell line | Using RNAi against FMOD | Induce glioma cell migration and invasion by promoting actin cytoskeleton remodeling pathway | [31] |