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Fig. 5 | Cancer Cell International

Fig. 5

From: Mutual regulation of JAG2 and PRAF2 promotes migration and invasion of colorectal cancer cells uncoupled from epithelial–mesenchymal transition

Fig. 5

No significant correlation between JAG2-induced cell invasion and migration and the canonical Notch signaling pathway. a When JAG2 was silenced or overexpressed in HCT116 and HT29 cells respectively, Western blot analyses showed that NCID protein levels were affected by altered expression level of JAG2. b When JAG2 was overexpressed in HT29 cells, JAG2 and NCID protein levels were examined by Western Blot analyses in JAG2-overexpression HT29 cells treated with DAPT (5 μM) or IMR-1 (1 μM). c, d Cell migration and invasion enhanced by JAG2-overexpression was not effectively repressed by Notch signaling pathway inhibitors (DAPT and IMR-1). Data are the mean ± SD. of three independent experiments. *P < 0.05 versus control

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