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Fig. 7 | Cancer Cell International

Fig. 7

From: Mutual regulation of JAG2 and PRAF2 promotes migration and invasion of colorectal cancer cells uncoupled from epithelial–mesenchymal transition

Fig. 7

Overexpression of JAG2 in HT29 cells affects the characteristics of exosomes. a Western blot analyses showed that overexpression of JAG2 up-regulated PRAF2 protein level; b altered JAG2 (overexpression of JAG2) and PRAF2 (downregulation of PRAF2 by siRNA) proteins in HT29 cells affected the number of secreted secretions; c when JAG2 was overexpressed in HT29 cells, and PRAF2 was silenced by siRNA or GW4869 (2.5 μM) treatment, Western Blot detected a decrease in the content of JAG2 and PRAF2 in exosomes compared with the control group. Data are the mean ± SD. of three independent experiments. *P < 0.05 versus control

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