Upregulation of NPL4 promotes bladder cancer cell proliferation by inhibiting DXO destabilization of cyclin D1 mRNA

Table 1 Correlation between NPL4 mRNA expression and clinicopathological characteristics

Characteristics	Number of patients (%)	NPL4 expression		P value^a
Characteristics	Number of patients (%)	Low (%)	High (%)	P value^a
Total no. of patients	35	18	17
Age (years)
≤ 63^b	17	9 (52.94)	8 (47.06)	1.000
> 63	18	9 (50.00)	9 (50.00)	1.000
Gender
Male	22	12 (54.55)	10 (45.45)	0.733
Female	13	6 (46.15)	7 (53.85)	0.733
Tumor size (cm)
≤ 3.0^c	22	14 (63.64)	8 (36.36)	0.035
> 3.0	13	3 (23.08)	10 (76.92)	0.035
Tumor grade
Low	21	10 (45.45)	11 (54.55)	0.733
High	14	8 (57.14)	6 (42.86)	0.733
T classification
Ta, T1	23	13 (56.52)	10 (43.48)	0.489
T2–T4	12	5 (41.67)	7 (58.33)	0.489
pN status
pN−	27	13 (48.15)	14 (51.85)	0.691
pN+	8	5 (62.50)	3 (37.50)	0.691
Tumor multiplicity
Unifocal	15	11 (41.67)	4 (41.67)	0.041
Multifocal	20	7 (41.67)	13 (41.67)	0.041

Significant associations are shown in italic face in the P value column (P value < 0.05)
^aChi square test
^bMedian age
^cMedian size

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