Fig. 5

MiR-503 suppresses cell proliferation and invasion of GC cells by targeting HMGA2. a The expression levels of HMGA2 in 46 GC tissues and adjacent normal tissues were investigated and qRT-PCR analyses. b Higher HMGA2 expression levels showed a negative association with lower miR-503 in GC tissues by Spearman correlation analysis (Fig. 5b, r = -− 0.442, P < 0.05). c The expression levels of HMGA2 were detected after MKN-45 cells were trasfected with pcDNA3.1-vector or pcDNA3.1-HMGA2. d Cell viability was showed at 24 h, 48 h, 72 h and 96 h after cell transfected with miR-NC, miR-503 mimic, pcDNA3.1-HMGA2, or pcDNA3.1-HMGA2 + miR-503 mimic in MKN-45 cells. e, f Transwell cell invasion assay and invasive cell number was showed at 48 h after cell transfected with miR-NC, miR-503 mimic, pcDNA3.1-HMGA2, or pcDNA3.1-HMGA2 + miR-503 mimic in MKN-45 cells. All values are presented as mean ± SD, *P < 0.05, ^#no statistical significance