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Fig. 5 | Cancer Cell International

Fig. 5

From: Vitamin E δ-tocotrienol sensitizes human pancreatic cancer cells to TRAIL-induced apoptosis through proteasome-mediated down-regulation of c-FLIPs

Fig. 5

The effect of VEDT on cell death and survival. a Time course of VEDT activity on decoy receptors and death receptor pathway (DR4, DR5, DCR1, DCR2, DCR3) and c-FLIPs in panel of pancreatic cancer cells by Western blot (n = 3). b Effect of transient ectopic transfection of c-FLIPs in pCMV6-AC-GFP plasmid vector on apoptosis in MiaPaCa-2 cells treated with VEDT for 24 h as measured by TUNEL and quantified by analytic microscopy (inset). Columns, means; bars, standard deviation (n = 3, **P < .01 and ***P < .001). c Effect of VEDT on caspase-8 enzymatic activity in Mia-GFP and Mia-FLIP cells. Columns, means; bars, standard deviation (n = 3, *P < .001 and ***P < .05). d Effect of VEDT on survival in Mia-GFP and Mia-FLIP cells. Columns, means; bars, standard deviation (n = 3, *P < .001, **P < .01, and ***P < .05)

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