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Fig. 4 | Cancer Cell International

Fig. 4

From: RETRACTED ARTICLE: LncRNA TUBA4B functions as a competitive endogenous RNA to inhibit gastric cancer progression by elevating PTEN via sponging miR-214 and miR-216a/b

Fig. 4

TUBA4B acts as a sponge for miR-214, miR-216a and miR-216b. a qRT-PCR analysis of the nuclear and cytoplasmic TUBA4B expression in MGC-803 and HGC-27 cells. b miRCode and miRWalk online database analysis for miRNAs that might bind to both TUBA4B and PTEN 3′-UTR. c RNA pull-down assay for measuring the interaction between TUBA4B and the indicated eight miRNAs in MGC-803 and HGC-27 cells. d–f Luciferase reporter assay in MGC-803 and HGC-27 cells co-transfected with wild-type or mutant TUBA4B reporter and control or miR-214/216a/b mimics. g, h qRT-PCR analysis of TUBA4B expression in GC cells and xenograft model after TUBA4B overexpression. i The Kaplan–Meier survival curve of GC patients with low and high miR-214, miR-216a and miR-216b expression in KM-plotter online database. *p < 0.05, **p < 0.01

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Cancer Cell International

ISSN: 1475-2867

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