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Fig. 10 | Cancer Cell International

Fig. 10

From: Harmine suppresses hyper-activated Ras–MAPK pathway by selectively targeting oncogenic mutated Ras/Raf in Caenorhabditis elegans

Fig. 10

Harmine had little effect on other LET-60 signaling pathway components. a and b Mild suppression of the number of ectopic vulvas, but not the Muv phenotype, in lin-15(n765 ts) mutants by harmine. c and d Harmine has no effect on lin-1(e1777lf) mutants. White arrows indicate pseudovulvas and black arrowheads indicate normal vulvas **p < 0.01. e Representative western blots of Ras levels in let-60(n1046) treated with tipifarnib (160 μM), harmine (160 μM), harmol (320 μM), or harmaline (320 μM). Harmine treatment had no effect on LET-60/Ras protein level

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Cancer Cell International

ISSN: 1475-2867

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