Skip to main content
Fig. 5 | Cancer Cell International

Fig. 5

From: Harmine suppresses hyper-activated Ras–MAPK pathway by selectively targeting oncogenic mutated Ras/Raf in Caenorhabditis elegans

Fig. 5

Harmine is the active Muv-suppressive component in the DCM and EtOAc fractions. a Structures of harmine, harmaline, and harmol. b Only harmine treatment suppresses the Muv phenotype in let-60(n1046gf). c Harmine reduces the percentage of Muv animals and the number of ectopic vulvas is in a dose-dependent manner. d and e Harmaline and harmol have little effect on the Muv phenotype in let-60(n1046gf). White arrows indicate pseudovulvas and black arrowheads indicate normal vulvas. *p < 0.05; **p < 0.01; ***p < 0.001 by one-way analysis of variance

Back to article page

Cancer Cell International

ISSN: 1475-2867

Contact us