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Fig. 7 | Cancer Cell International

Fig. 7

From: Harmine suppresses hyper-activated Ras–MAPK pathway by selectively targeting oncogenic mutated Ras/Raf in Caenorhabditis elegans

Fig. 7

Harmine reverses the phenotype induced by a LET-60 hyper-activating mutation. a and b Harmine treatment could suppress the Muv phenotype in let-60(n1700gf). c and d Harmine suppresses the abnormal gonad phenotype (small stacked oocytes) in the LET-60 hyper-activation mutation strain let-60(ga89gf). Red lines in c outline the oocytes. White arrows indicate pseudovulvas and black arrowheads indicate normal vulvas. **p < 0.01; ***p < 0.001 by unpaired Student’s t-test

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