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Table 1 Correlation of serum IQGAP3, B7-H4 and COX-2 levels with clinicopathological features in 118 CRC patients

From: Clinical value of detecting IQGAP3, B7-H4 and cyclooxygenase-2 in the diagnosis and prognostic evaluation of colorectal cancer

Parameters

Patients

IQGAP3

P

B7-H4

P

COX-2

P

n (%)

Mean ± SD, pg/ml

Mean ± SD, ng/ml

 

Mean ± SD, ng/ml

Age (years)

  

0.023a

 

0.282a

 

0.102a

 ≤ 60

53 (44.9)

300.26 ± 104.31

 

99.34 ± 14.23

 

47.12 ± 11.23

 

 > 60

65 (55.1)

322.47 ± 99.67

 

97.25 ± 15.88

 

48.38 ± 11.35

 

Sex

  

0.506a

 

0.173a

 

0.188a

 Female

49 (41.5)

316.03 ± 104.98

 

96.53 ± 13.44

 

46.99 ± 12.56

 

 Male

69 (58.5)

311.54 ± 101.42

 

98.96 ± 15.43

 

48.32 ± 13.45

 

Tumor site

  

0.208a

 

0.196a

 

0.234a

 Colon

66 (55.9)

316.38 ± 99.03

 

97.24 ± 15.36

 

47.34 ± 12.03

 

 Rectum

52 (44.1)

312.35 ± 103.54

 

95.87 ± 12.14

 

48.87 ± 13.67

 

Tumor size (cm)

  

0.052a

 

0.358a

 

0.162a

 ≤ 4

63 (53.4)

311.93 ± 90.17

 

98.76 ± 15.67

 

47.33 ± 12.28

 

 > 4

55 (46.6)

325.00 ± 87.65

 

101.11 ± 10.42

 

50.12 ± 14.66

 

T stage

  

0.001b

 

0.024b

 

0.016b

 T1

22 (18.6)

180.33 ± 71.10

 

81.23 ± 9.32

 

37.12 ± 11.02

 

 T2

32 (27.1)

185.57 ± 84.10

 

89.44 ± 10.53

 

45.33 ± 9.89

 

 T3

34 (28.8)

272.78 ± 79.20

 

96.56 ± 17.53

 

51.02 ± 10.17

 

 T4

30 (25.4)

382.71 ± 76.76

 

103.30 ± 11.88

 

53.44 ± 8.76

 

N stage

  

< 0.001b

 

0.004b

 

0.008b

 N0

48 (40.7)

252.97 ± 88.16

 

87.54 ± 12.23

 

38.41 ± 9.76

 

 N1

39 (33.1)

323.11 ± 80.03

 

97.65 ± 14.08

 

45.67 ± 11.65

 

 N2

31 (26.3)

392.02 ± 88.68

 

104.45 ± 9.88

 

51.87 ± 10.03

 

Differentiation degree

  

0.086b

 

0.052b

 

0.109b

 Well

56 (47.5)

272.75 ± 75.60

 

93.33 ± 13.33

 

40.89 ± 10.33

 

 Moderate

50 (42.4)

351.91 ± 90.22

 

93.37 ± 12.23

 

45.38 ± 11.65

 

 Poor

12 (10.2)

358.57 ± 91.57

 

100.80 ± 13.89

 

51.70 ± 11.78

 

Retrieved LN

  

0.017a

 

0.085a

 

0.256a

 ≤ 12

61 (51.7)

354.78 ± 88.75

 

97.56 ± 12.80

 

47.91 ± 12.36

 

 > 12

57 (48.3)

266.63 ± 96.23

 

96.38 ± 16.92

 

48.56 ± 11.67

 

TNM stage

  

< 0.001a

 

0.002a

 

< 0.001a

 I + II

48 (40.7)

270.22 ± 102.70

 

88.23 ± 15.67

 

39.21 ± 14.22

 

 III

70 (59.3)

338.86 ± 92.78

 

108.12 ± 14.21

 

51.87 ± 11.78

 
  1. One hundred eighteen CRC patients who met the inclusion criteria were analyzed in this study. The correlation between clinicopathological characteristics and serum tumor markers were analyzed
  2. LN, lymph nodes; TNM, tumor-node-metastasis; SD, standard deviation
  3. aBy Mann–Whitney U test
  4. bBy Kruskal–Wallis test