Clinical value of detecting IQGAP3, B7-H4 and cyclooxygenase-2 in the diagnosis and prognostic evaluation of colorectal cancer

Table 2 Correlation of tissue IQGAP3, B7-H4 and COX-2 expression levels with clinicopathological features in 118 CRC patients

Parameters	Patients	IQGAP3		P	B7-H4		P	COX-2		P
Parameters	n (%)	Low	High	P	Low	High	P	Low	High	P
	118	61	57		52	66		55	63
Age (years)				0.605			0.083			0.394
≤ 60	53	26	27		28	25		27	26
> 60	65	35	30		24	41		28	37
Sex				0.081			0.597			0.418
Female	49	30	19		23	26		25	24
Male	69	31	38		29	40		30	39
Tumor site				0.678			0.685			0.777
Colon	66	33	33		28	38		30	36
Rectum	52	28	24		24	28		25	27
Tumor size (cm)				0.369			0.115			0.213
≤ 4	63	35	28		32	31		26	37
> 4	55	26	29		20	35		29	26
T stage				< 0.001			< 0.001			< 0.001
T1	22	18	4		20	2		18	4
T2	32	26	6		18	14		25	7
T3	34	15	19		11	23		9	25
T4	30	2	28		3	27		3	27
N stage				0.003			< 0.001			< 0.001
N0	48	30	18		33	15		36	12
N1	39	23	16		15	24		14	25
N2	31	8	23		4	27		5	26
Differentiation degree				0.427			0.102			0.239
Well	56	30	26		30	26		29	27
Moderate	50	26	24		19	31		23	27
Poor	12	5	7		3	9		3	9
Retrieved LN				0.201			0.678			0.873
≤ 12	61	35	26		28	33		28	33
> 12	57	26	31		24	33		27	30
TNM stage				0.007			0.001			< 0.001
I + II	48	32	16		30	18		39	9
III	70	29	41		22	48		16	54

One hundred eighteen CRC patients who met the inclusion criteria were analyzed in this study. The correlation between clinicopathological characteristics and tissue tumor markers were analyzed
LN, lymph nodes; TNM, tumor-node-metastasis

ISSN: 1475-2867