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Table 3 IQGAP3, B7-H4, COX-2, CEA and CA19-9 levels in different patient groups

From: Clinical value of detecting IQGAP3, B7-H4 and cyclooxygenase-2 in the diagnosis and prognostic evaluation of colorectal cancer

Tumor markers

 

Control group

CRC group

All

T1

T2

T3

T4

 

Cases (n)

85

118

22

32

34

30

IQGAP3

Levels (mean ± SD, pg/ml)

191.97 ± 103.96

312.68 ± 101.91

180.33 ± 71.10

185.57 ± 84.10

272.78 ± 79.20

382.71 ± 76.76

P

 

< 0.001#

= 0.284*

= 0.412**

< 0.001***

< 0.001##

CV

54.2

32.6

39.4

45.3

29.0

20.1

B7-H4

Levels (mean ± SD, ng/ml)

64.78 ± 16.73

97.85 ± 15.56

81.23 ± 9.32

89.44 ± 10.53

96.56 ± 17.53

103.30 ± 11.88

P

 

< 0.001#

= 0.003*

= 0.001**

< 0.001***

< 0.001##

CV

25.8

15.9

11.5

11.8

18.2

11.5

COX-2

Levels (mean ± SD, ng/ml)

25.78 ± 16.09

48.55 ± 13.43

37.12 ± 11.02

45.33 ± 9.89

51.02 ± 10.17

53.44 ± 8.76

P

 

< 0.001#

= 0.001*

< 0.001**

< 0.001***

< 0.001##

CV

62.4

27.7

29.7

21.8

19.9

16.4

CEA

Levels (mean ± SD, ng/ml)

3.41 ± 1.27

6.22 ± 4.49

5.34 ± 1.17

5.92 ± 1.85

6.08 ± 3.82

6.34 ± 2.14

P

 

< 0.001#

= 0.004*

= 0.001**

< 0.001***

< 0.001##

CV

37.2

72.2

21.9

31.3

62.8

33.8

CA19-9

Levels (mean ± SD, U/ml)

19.24 ± 10.08

29.92 ± 8.97

27.19 ± 8.87

29.81 ± 9.43

30.90 ± 10.16

31.5 ± 9.58

P

 

< 0.001#

< 0.001*

< 0.001**

< 0.001***

< 0.001##

CV

52.4

30.0

32.6

31.6

32.9

30.4

  1. 118 CRC patients were set as CRC group including T1–T4 groups and 85 healthy individuals were set as control group. Serum levels of IQGAP3, B7-H4, COX-2, CEA and CA19-9 in CRC group were significantly higher than those in control group (IQGAP3: 312.68 ± 101.91 vs. 191.97 ± 103.96 P < 0.001; B7-H4: 97.85 ± 15.56 vs. 64.78 ± 16.73, P = 0.003; COX-2: 48.55 ± 13.43 vs. 25.78 ± 16.09 P < 0.001; CEA: 6.62 ± 4.49 vs. 3.41 ± 1.27, P < 0.001; CA19-9: 29.92 ± 8.97 vs. 19.24 ± 10.08, P < 0.001). However, IQGAP3 in T1 and T2 groups were not higher than that in control group (T1 180.33 ± 71.10: Control 191.97 ± 103.96, P = 0.284; T2 185.57 ± 84.10: Control 191.97 ± 103.96, P = 0.412). CVs of each group were also shown
  2. CRC, colorectal cancer; SD, standard deviation; CV, coefficient of variation
  3. * Control group vs. T1 group
  4. ** Control group vs. T2 group
  5. *** Control group vs. T3 group
  6. #Control group vs. all group
  7. ##Control group vs. T4 group