Table 2 Univariate and multivariate analysis of clinicopathological variables and PFKFB4 associated with disease-free survival

Age (years)

 ≤ 50

1

–

–

–

 > 50

1.12 (0.58–2.14)

0.734

–

–

Menopausal status

 Premenopausal

1

–

–

–

 Postmenopausal

1.13 (0.58–2.17)

0.726

–

–

Tumor size (cm)

 ≤ 2

1

–

–

–

 > 2, ≤ 5

1.09 (0.56–2.12)

0.800

–

–

 > 5

1.00 (0.13–7.49)

0.998

–

–

 Cannot be measured

1.29 (0.17–9.69)

0.807

–

–

Lymph node status

 Negative

1

–

–

–

 Positive

1.46 (0.76–2.81)

0.253

–

–

Grade

 Grade 1–2

1

–

–

–

 Grade 3

1.10 (0.50–2.43)

0.810

–

–

 Unknown

1.53 (0.71–3.29)

0.281

–

–

ER status

 Negative

1

–

1

–

 Positive

0.58 (0.29–1.14)

0.112

0.51 (0.13–2.09)

0.353

PR status

 Negative

1

–

–

–

 Positive

0.66 (0.34–1.30)

0.230

–

–

HER2 status

 Negative

1

–

1

–

 Positive

0.62 (0.32–1.22)

0.166

1.26 (0.44–3.61)

0.671

Subtype^a

 Luminal

1

–

1

–

 HER2-enriched

0.61 (0.20–1.82)

0.373

0.26 (0.059–1.19)

0.083

 Triple-negative

2.19 (1.10–4.35)

0.025

1.22 (0.24–6.06)

0.812

PFKFB4

 Negative

1

–

1

–

 Positive

2.52 (1.24–5.11)

0.010

2.42 (1.17–5.00)

0.017