Fig. 8

The inhibitor of β-catenin accumulation XAV-939 could reverse DKK1 knockdown-induced MMP7 protein expression and cell invasion in MCF-7 and MDA-MB-231 cells. a Western blot assay suggested XAV-939 could inhibit β-catenin nuclear accumulation in MCF-7 and MDA-MB-231 cells treated with DKK1 shRNA. Lamin B1 is used as an internal control. Results are presented as mean ± SEM, ***p < 0.001, n = 5 per group, Student's test was used. b Western blot assay suggested XAV-939 could reverse DKK1 knockdown-induced MMP7 protein expression in MCF-7 and MDA-MB-231 cells. Results are presented as mean ± SEM, **p < 0.01, n = 5 per group, Student's test was used. c Transwell chamber coated with Matrigel assay showed XAV-939 could reverse DKK1 knockdown-induced the cell invasion in MCF-7 and MDA-MB-231 cells. Results are presented as mean ± SEM, ***p < 0.001, n = 5 per group, Student's test was used