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Fig. 5 | Cancer Cell International

Fig. 5

From: Relation of AURKB over-expression to low survival rate in BCRA and reversine-modulated aurora B kinase in breast cancer cell lines

Fig. 5

Overexpression of aurora B relates to lower survival rate in BRCA The heatmap of over-expressed genes in TNBC subtype (a), HER2 subtype (b), and luminal subtype (c), showing that AURKB genes ranked 19, 48, and 49 in the TNBC, HER2, and luminal subtypes. d Heatmap of the four tumor-related genes of AURKB, TGFB1, MMP9, and TIMP1 expressed in normal and breast cancer tumor tissues; data were acquired from UALCAN. e Transcript expression levels of AURKB, TGFB1, MMP9, and TIMP1 in BRCA based on breast cancer subclasses, indicating the over-expressed AURKB, TGFB1, MMP9, and TIMP1 genes in the tumor tissues; data were acquired from UALCAN by analyzing the TCGA samples. The overall survival at different AURKB expression levels in the TCGA (f), GSE3141 (g), and GSE3493_U133A database (h), demonstrating the influence of AURKB level on patient survival; data were acquired form the PROGgeneV2

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