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Table 1 Therapeutic approaches using, microRNAs against colon CSCs and pericytes [89, 90]

From: Effects of pericytes and colon cancer stem cells in the tumor microenvironment

miRNA Expression level Target Findings Technique References
21* ITGβ4 A prognostic tool, proliferation, invasion and metastasis qPCR https://doi.org/10.4161/epi.26842 [91]
23a E-cadherin Induced EMT process associated CRC metastasis qPCR https://doi.org/10.1093/carcin/bgt274 [92]
ZO-1 Increasing vascular permeability and migration   https://doi.org/10.3892/etm.2017.4972 [93]
24* Paxillin Inhibited the killing effect of NK cells to colorectal cancer cells qRT-PCR and Western blot https://doi.org/10.1016/j.biopha.2018.02.024 [94]
34a Inh3 Increased lymph node infiltration and metastasis in colon cancer patients miRNA target prediction software miRWalk https://doi.org/10.1053/j.gastro.2017.04.017 [95]
126 BCL-2 and p53 Potential tumour suppressor qRT-PCR https://doi.org/10.1016/j.yexcr.2015.10.004 [96]
137 TCF4 Suppresses cell proliferation, migration and invasion in colon cancer cell lines RT-qPCR https://doi.org/10.3892/ol.2018.8364 [97]
143* IGF-IR Inhibited cell proliferation, migration, tumor growth, angiogenesis and increased chemosensitivity to oxaliplatin treatment qRT-PCR and western blot https://doi.org/10.4161/cc.24477 [98]
150 c-Myb Inhibits cell proliferation, induces cell apoptosis and inhibits cell migration and invasion in human CRC cells qRT-PCR, western blot and DNA constructs and luciferase target assay https://doi.org/10.1111/jcmm.12398 [99]
200 ZEB1, ETS1 and FLT1 Increased EMT TaqMan MicroRNA assays http://doi.org/10.1136/gutjnl-2011-301846 [100]
203 SOCS3 Potential for metastasis; promoted the differentiation of monocytes to M2 macrophages RT-qPCR and Gene Set Enrichment Analysis (GSEA)
TargetScan and miRanda
https://doi.org/10.18632/oncotarget.20009 [101]
https://doi.org/10.1177/1947601911425832 [102]
221 RECK, RelA and STAT3 Migration and invasion in vitro and metastasis in vivo qRT-PCR and western blot
qRT-PCR and western blot
https://doi.org/10.1016/j.febslet.2013.11.014 [103]
https://doi.org/10.1053/j.gastro.2014.06.006 [104]
1246 CCNG2 Promoted the proliferation, colony formation, invasion and migration, and inhibited the apoptosis RT-qPCR and Dual luciferase reporter assay https://doi.org/10.3892/mmr.2015.4557 [105]
  1. ↑ = ; ↓ = *clinical trials