Skip to main content

Table 1 Therapeutic approaches using, microRNAs against colon CSCs and pericytes [89, 90]

From: Effects of pericytes and colon cancer stem cells in the tumor microenvironment

miRNA Expression level Target Findings Technique References
21* ITGβ4 A prognostic tool, proliferation, invasion and metastasis qPCR [91]
23a E-cadherin Induced EMT process associated CRC metastasis qPCR [92]
ZO-1 Increasing vascular permeability and migration [93]
24* Paxillin Inhibited the killing effect of NK cells to colorectal cancer cells qRT-PCR and Western blot [94]
34a Inh3 Increased lymph node infiltration and metastasis in colon cancer patients miRNA target prediction software miRWalk [95]
126 BCL-2 and p53 Potential tumour suppressor qRT-PCR [96]
137 TCF4 Suppresses cell proliferation, migration and invasion in colon cancer cell lines RT-qPCR [97]
143* IGF-IR Inhibited cell proliferation, migration, tumor growth, angiogenesis and increased chemosensitivity to oxaliplatin treatment qRT-PCR and western blot [98]
150 c-Myb Inhibits cell proliferation, induces cell apoptosis and inhibits cell migration and invasion in human CRC cells qRT-PCR, western blot and DNA constructs and luciferase target assay [99]
200 ZEB1, ETS1 and FLT1 Increased EMT TaqMan MicroRNA assays [100]
203 SOCS3 Potential for metastasis; promoted the differentiation of monocytes to M2 macrophages RT-qPCR and Gene Set Enrichment Analysis (GSEA)
TargetScan and miRanda [101] [102]
221 RECK, RelA and STAT3 Migration and invasion in vitro and metastasis in vivo qRT-PCR and western blot
qRT-PCR and western blot [103] [104]
1246 CCNG2 Promoted the proliferation, colony formation, invasion and migration, and inhibited the apoptosis RT-qPCR and Dual luciferase reporter assay [105]
  1. ↑ = ; ↓ = *clinical trials