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Table 3 Univariate and multivariable Cox regression analyses

From: Comprehensive bioinformatics analysis reveals potential lncRNA biomarkers for overall survival in patients with hepatocellular carcinoma: an on-line individual risk calculator based on TCGA cohort

  Univariate analysis Multivariate analysis
HR 95% CI P-value Coefficient HR 95% CI P-value
Model group (n = 348)
 Age (high/low) 1.254 0.887–1.772 0.199 0.204 1.227 0.838–1.797 0.294
 Gender (male/female) 0.817 0.573–1.164 0.264 − 0.123 0.884 0.602–1.298 0.530
 AJCC PT (T4, T3/T2, T1) 2.548 1.794–3.617 < 0.001 0.614 1.847 0.244–13.991 0.553
 AJCC PN (N2, N1/N0) 1.509 1.048–2.174 0.027 − 0.132 0.876 0.542–1.417 0.590
 AJCC PM (MX, M1/M0) 1.674 1.162–2.413 0.006 0.622 1.863 1.159–2.993 0.010
 AJCC stage (IV, III/II, I) 2.442 1.685–3.540 < 0.001 0.169 1.184 0.158–8.868 0.870
 LncRNA risk prediction score (high/low) 4.140 2.801–6.120 < 0.001 1.421 4.141 2.705–6.340 < 0.001
Validation cohort (n = 348)
Age (year) 2.057 1.421–2.978 < 0.001 0.528 1.696 1.129–2.550 0.011
Gender (male/female) 0.777 0.542–1.113 0.169 − 0.062 0.940 0.629–1.403 0.761
AJCC PT (T4, T3/T2, T1) 1.890 1.294–2.762 0.001 0.433 1.541 0.201–11.816 0.677
AJCC PN (N2, N1/N0) 1.635 1.143–2.339 0.007 − 0.084 0.919 0.585–1.443 0.714
AJCC PM (MX, M1/M0) 1.681 1.171–2.413 0.005 0.392 1.480 0.940–2.330 0.091
AJCC stage (IV, III/II, I) 1.687 1.123–2.534 0.012 − 0.005 0.995 0.134–7.405 0.996
LncRNA risk prediction score (high/low) 3.891 2.615–5.788 < 0.001 1.292 3.639 2.345–5.645 < 0.001
  1. The median of LncRNA risk prediction score scores was used as the cut-off values to stratify hepatocellular carcinoma patients into high risk group and low risk group
  2. AJCC the American Joint Committee on Cancer, HR hazard ratio, CI confidence interval