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Table 3 Univariate and multivariable Cox regression analyses

From: Comprehensive bioinformatics analysis reveals potential lncRNA biomarkers for overall survival in patients with hepatocellular carcinoma: an on-line individual risk calculator based on TCGA cohort

 

Univariate analysis

Multivariate analysis

HR

95% CI

P-value

Coefficient

HR

95% CI

P-value

Model group (n = 348)

 Age (high/low)

1.254

0.887–1.772

0.199

0.204

1.227

0.838–1.797

0.294

 Gender (male/female)

0.817

0.573–1.164

0.264

− 0.123

0.884

0.602–1.298

0.530

 AJCC PT (T4, T3/T2, T1)

2.548

1.794–3.617

< 0.001

0.614

1.847

0.244–13.991

0.553

 AJCC PN (N2, N1/N0)

1.509

1.048–2.174

0.027

− 0.132

0.876

0.542–1.417

0.590

 AJCC PM (MX, M1/M0)

1.674

1.162–2.413

0.006

0.622

1.863

1.159–2.993

0.010

 AJCC stage (IV, III/II, I)

2.442

1.685–3.540

< 0.001

0.169

1.184

0.158–8.868

0.870

 LncRNA risk prediction score (high/low)

4.140

2.801–6.120

< 0.001

1.421

4.141

2.705–6.340

< 0.001

Validation cohort (n = 348)

Age (year)

2.057

1.421–2.978

< 0.001

0.528

1.696

1.129–2.550

0.011

Gender (male/female)

0.777

0.542–1.113

0.169

− 0.062

0.940

0.629–1.403

0.761

AJCC PT (T4, T3/T2, T1)

1.890

1.294–2.762

0.001

0.433

1.541

0.201–11.816

0.677

AJCC PN (N2, N1/N0)

1.635

1.143–2.339

0.007

− 0.084

0.919

0.585–1.443

0.714

AJCC PM (MX, M1/M0)

1.681

1.171–2.413

0.005

0.392

1.480

0.940–2.330

0.091

AJCC stage (IV, III/II, I)

1.687

1.123–2.534

0.012

− 0.005

0.995

0.134–7.405

0.996

LncRNA risk prediction score (high/low)

3.891

2.615–5.788

< 0.001

1.292

3.639

2.345–5.645

< 0.001

  1. The median of LncRNA risk prediction score scores was used as the cut-off values to stratify hepatocellular carcinoma patients into high risk group and low risk group
  2. AJCC the American Joint Committee on Cancer, HR hazard ratio, CI confidence interval