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Fig. 4 | Cancer Cell International

Fig. 4

From: Caveolin-1 enhances brain metastasis of non-small cell lung cancer, potentially in association with the epithelial-mesenchymal transition marker SNAIL

Fig. 4

a Effect of Cav-1 knockdown on the migration of human SQC cell lines. Cav-1 knockdown significantly decreased H1299 and H157 cell invasion, as shown by wound gap distance. b Effect of Cav-1 knockdown on the invasion of human SQC cell lines. Cav-1 knockdown significantly decreased H1299 and H157 cell invasion, as shown by cell counts per field. Bar graphs show the mean ± standard error of the mean (***P < 0.001). c Altered expression of EMT markers and regulators by Cav-1 knockdown in both cell lines. Cav-1 knockdown reduced the expression of EMT markers, including N-cadherin and fibronectin, and reversely increased the expression of E-cadherin, representative epithelial marker. Among the EMT-regulating genes, SNAIL was consistently reduced by Cav-1 knockdown in both cell lines

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Cancer Cell International

ISSN: 1475-2867

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