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Fig. 4 | Cancer Cell International

Fig. 4

From: Long non-coding RNA MEG3 inhibits cervical cancer cell growth by promoting degradation of P-STAT3 protein via ubiquitination

Fig. 4

The effect of the MEG3-STAT3 regulatory axis on the proliferation and apoptosis of cervical cancer cells. Cells were treated with nifuroxazide (STAT3 phosphorylation inhibitor, Selleck Chemicals) at a final concentration of 20 mM in dimethyl sulfoxide (DMSO). Western blot analysis of P-STAT3 protein expression suggested that nifuroxazide may effectively decrease the level of P-STAT3 protein and reverse the regulation of P-STAT3 protein by MEG3 shRNA (a). The clone formation experiment results suggest that nifuroxazide may reverse the effect of MEG3 shRNA on the promotion of the proliferation of cervical cancer cells (b, d). Flow cytometry results indicate that nifuroxazide may reverse the effect of MEG3 shRNA on the inhibition of apoptosis of cervical cancer cells (c, e). *P < 0.05

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