Table 1 Correlation between miR-29c expression and patients’ parameters
Patient’s parameters | Status of miR-29c expression | ||
|---|---|---|---|
Low (n = 51) | High (n = 51) | P | |
Sex, male/female | 31/20 | 29/22 | 0.423 |
Median age, years (range) | 54 (19–93) | 58 (18–87) | 0.968 |
Median WBC, × 109/L (range) | 12 (1.1–201) | 8.1 (0.3–528) | 0.517 |
Median hemoglobin, g/L (range) | 76.5 (34–138) | 71 (32–113) | 0.202 |
Median platelets, × 109/L (range) | 42 (3–447) | 37 (4–399) | 0.196 |
BM blasts, % (range) | 53 (6.5–94.5) | 42.5 (1.0–97.5) | 0.085 |
FAB classification | 0.002 | ||
 M0 | 1 | 0 |  |
 M1 | 5 | 4 |  |
 M2 | 23 | 24 |  |
 M3 | 1 | 14 |  |
 M4 | 14 | 6 |  |
 M5 | 6 | 3 |  |
 M6 | 1 | 0 |  |
WHO classification | 0.007 | ||
 t (8;21) | 7 | 5 |  |
 t (15;17) | 1 | 13 |  |
 AML without maturation | 4 | 4 |  |
 AML with maturation | 18 | 18 |  |
 Acute myelomonocytic leukemia | 15 | 7 |  |
 Acute monoblastic and monocytic leukemia | 5 | 2 |  |
 Acute erythroid leukemia | 1 | 0 |  |
 No data | 0 | 2 |  |
Risk classification | 0.013 | ||
 Low | 8 | 20 |  |
 Intermediate | 35 | 23 |  |
 High | 8 | 4 |  |
 No data | 0 | 4 |  |
Karyotype | 0.006 | ||
 Normal | 27 | 18 |  |
 t (8;21) | 7 | 7 |  |
 t (15;17) | 1 | 13 |  |
 11q23 | 1 | 0 |  |
 Complex | 7 | 4 |  |
 Others | 8 | 5 |  |
 No data | 0 | 4 |  |
Gene mutation* | |||
 C-KIT (±) | 2/47 | 1/47 | 1.000 |
 FLT3 (±) | 7/42 | 6/42 | 1.000 |
 NPM1 (±) | 5/44 | 5/43 | 1.000 |
 C/EBPA (±) | 7/42 | 5/43 | 0.759 |
 N/K-RAS (±) | 3/46 | 4/45 | 1.000 |
 IDH1/2 (±) | 3/46 | 3/40 | 0.704 |
 DNMT3A (±) | 6/43 | 3/40 | 0.494 |
 U2AF1 (±) | 1/48 | 4/39 | 0.332 |
 CR (±) | 33/17 | 26/21 | 0.305 |