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Table 2 Univariate and multivariate analyses of prognostic factors for overall survival in whole-cohort AML patients

From: Down-regulation of miR-29c is a prognostic biomarker in acute myeloid leukemia and can reduce the sensitivity of leukemic cells to decitabine

Prognostic factors

Univariate analysis

Multivariate analysis

Hazard ratio (95% CI)

P value

Hazard ratio (95% CI)

P value

Age (> 60/≤ 60 year)

2.840 (1.708–4.723)

< 0.001

1.381 (0.553–3.449)

0.489

WBC (≥ 30 × 109/< 30 × 109/L)

2.111 (1.424–3.127)

< 0.001

1.572 (0.420–4.132)

0.381

karyotype grouping

1.932 (1.567–2.383)

< 0.001

1.967 (1.375–2.841)

0.001

miR-29c expression

2.398 (1.427–4.032)

0.001

2.336 (1.026–5.319)

0.033

K/N-RAS mutation (±)

1.622 (0.840–3.131)

0.150

1.115 (0.147–8.467)

0.916

U2AF1 mutation (±)

1.814 (0.732–4.500)

0.199

1.014 (0.492–5.806)

0.986

FLT3 mutation (±)

1.109 (0.577–2.132)

0.757

–

–

  1. +: positive; −: negative
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Cancer Cell International

ISSN: 1475-2867

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