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Table 2 Univariate and multivariate analyses of prognostic factors for overall survival in whole-cohort AML patients

From: Down-regulation of miR-29c is a prognostic biomarker in acute myeloid leukemia and can reduce the sensitivity of leukemic cells to decitabine

Prognostic factors Univariate analysis Multivariate analysis
Hazard ratio (95% CI) P value Hazard ratio (95% CI) P value
Age (> 60/≤ 60 year) 2.840 (1.708–4.723) < 0.001 1.381 (0.553–3.449) 0.489
WBC (≥ 30 × 109/< 30 × 109/L) 2.111 (1.424–3.127) < 0.001 1.572 (0.420–4.132) 0.381
karyotype grouping 1.932 (1.567–2.383) < 0.001 1.967 (1.375–2.841) 0.001
miR-29c expression 2.398 (1.427–4.032) 0.001 2.336 (1.026–5.319) 0.033
K/N-RAS mutation (±) 1.622 (0.840–3.131) 0.150 1.115 (0.147–8.467) 0.916
U2AF1 mutation (±) 1.814 (0.732–4.500) 0.199 1.014 (0.492–5.806) 0.986
FLT3 mutation (±) 1.109 (0.577–2.132) 0.757
  1. +: positive; −: negative