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Table 3 Multivariate Cox proportional hazard analyses of H19 rs4930101, rs2735970, and rs11042170 of in association with DFS and OS in advanced CRC patients

From: Functional polymorphisms of the lncRNA H19 promoter region contribute to the cancer risk and clinical outcomes in advanced colorectal cancer

Stratification

DFS

OS

Adjusted HR

95% CIb

P a

Adjusted HR

95% CIb

P a

Body weight, kg

 rs4930101GG vs. GT/TT

0.97

0.51–1.85

0.924

1.04

0.25–4.35

0.955

 rs2375970AA vs. GA/GG

0.87

0.48–1.59

0.658

1.64

0.49–5.56

0.423

 rs11042170 AA vs. GA/GG

1.26

0.87–1.83

0.215

1.67

0.81–3.45

0.168

 Combined genotypes ≤ 1 vs. > 1

1.18

0.79–1.76

0.421

1.79

1.09–2.94

0.002

Smoking

 rs4930101GG vs. GT/TT

0.84

0.53–1.31

0.434

1.56

0.96–2.54

0.073

 rs2375970AA vs. GA/GG

1.01

0.62–1.63

0.975

1.40

0.86–2.26

0.075

 rs11042170 AA vs. GA/GG

1.33

1.00–1.75

0.047

0.76

0.43–1.32

0.325

 Combined genotypes ≤ 1 vs. > 1

2.58

1.89–3.53

0.001

2.64

1.84–3.88

0.008

First-degree family history of cancer

 rs4930101GG vs. GT/TT

0.82

0.53–1.27

0.368

1.19

0.42–3.32

0.742

 rs2375970AA vs. GA/GG

1.02

0.63–1.64

0.952

1.40

0.50–3.92

0.523

 rs11042170 AA vs. GA/GG

1.23

0.94–1.62

0.139

1.63

0.90–2.93

0.105

 Combined genotypes ≤ 1 vs. > 1

1.22

0.90–1.65

0.203

2.75

1.17–6.60

0.006

  1. aP values were calculated by Multivariate Cox regression analyses adjusted for age, gender, body weight and first-degree family history of cancer status
  2. bAdjusted HR and 95% CI values were calculated by Multivariate Cox regression analyses adjusted for age, gender, body weight smoking status and first-degree family history of cancer status