Fig. 2

Inhibition of YAP overcame the multi-drug resistance of BEL/FU cells. a, b The assessment of the proliferation of BEL/FU cells after treatment with 5-Fu (0.3 mg/ml) or DOX (2 µmol/ml) with or without the YAP antagonist verteporfin (0.3 µg/ml) by CCK-8 assay. c, d The IC₅₀ values of 5-Fu or DOX in BEL/FU cells in the presence of verteporfin or PBS. e, f The colony formation of BEL/FU cells was assessed under treatment with 5-Fu (0.3 mg/ml) or DOX (2 µmol/ml) with or without verteporfin (0.3 µg/ml). g–j Apoptosis was measured in BEL/FU cells with or without YAP knockdown after treatment with 5-Fu (0.3 mg/ml) or DOX (2 µmol/ml) for 48 h by flow cytometry. Data are presented as the mean ± SD. **p < 0.01