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Table 2 Cox regression analysis of survival for ever smokers among NSCLC patients

From: Smoking history influences the prognostic value of peripheral naïve CD4+ T cells in advanced non-small cell lung cancer

Variables OS PFS
HR (95% CI) P value HR (95% CI) P value
Univariate analysis
 Age (years)
  < 60 1   1  
  ≥ 60 1.29 (0.64–2.58) 0.468 1.25 (0.66–2.34) 0.488
 Gender
  Female 1   1  
  Male 1.26 (0.30–5.30) 0.746 1.22 (0.36–4.08) 0.747
 Performance status
  0 1   1  
  1–2 1.76 (0.76–4.04) 0.18 1.41 (0.70–2.80) 0.331
 cStage
  III 1   1  
  IV 1.35 (0.66–2.75) 0.404 1.84 (0.96–3.53) 0.066
 Histology
  Non-AD 1   1  
  AD 1.37 (0.70–2.66) 0.352 1.71 (0.93–3.15) 0.183
 Tumor differentiation
  Well/moderate 1   1  
  Poor 1.58 (0.80–3.12) 0.187 1.14 (0.61–2.14) 0.677
 Naive CD4+
  Low 1   1  
  High 0.35 (0.17–0.70) 0.001 0.60 (0.32–1.12) 0.09
 Memory CD4+
  Low 1   1  
  High 1.51 (0.76–2.98) 0.223 1.36 (0.73–2.51) 0.298
 Naive CD8+
  Low 1   1  
  High 0.72 (0.36–1.41) 0.335 0.54 (0.29–1.01) 0.037
 Memory CD8+
  Low 1   1  
  High 1.24 (0.63–2.44) 0.519 1.50 (0.81–2.77) 0.175
 CD4+ naive/memory
  Low 1   1  
  High 0.48 (0.24–0.97) 0.03 0.78 (0.42–1.44) 0.411
 CD8+ naive/memory
  Low 1   1  
  High 0.69 (0.35–1.36) 0.279 0.53 (0.28–0.99) 0.032
 Naive CD8/CD4
  Low 1   1  
  High 1.26 (0.64–2.47) 0.491 0.89 (0.48–1.63) 0.708
 Memory CD8/CD4
  Low 1   1  
 High 1.35 (0.68–2.64) 0.377 1.56 (0.84–2.87) 0.133
Multivariate analysis
 Naive CD4+
  Low 1   1  
  High 0.11 (0.02–0.55) 0.007 0.73 (0.35–1.52) 0.400
 CD4+ naive/memory
  Low 1   
  High 3.63 (0.77–16.95) 0.101
 Naive CD8+
  Low   1  
  High 0.69 (0.11–4.17) 0.693
 CD8+ naive/memory
  Low   1  
  High 0.80 (0.12–5.03) 0.815
 cStage
  III   1  
  IV 1.97 (0.99–3.92) 0.051