Table 2 Cox regression analysis of survival for ever smokers among NSCLC patients

Univariate analysis

 Age (years)

  < 60

1

1

  ≥ 60

1.29 (0.64–2.58)

0.468

1.25 (0.66–2.34)

0.488

 Gender

  Female

1

1

  Male

1.26 (0.30–5.30)

0.746

1.22 (0.36–4.08)

0.747

 Performance status

  0

1

1

  1–2

1.76 (0.76–4.04)

0.18

1.41 (0.70–2.80)

0.331

 cStage

  III

1

1

  IV

1.35 (0.66–2.75)

0.404

1.84 (0.96–3.53)

0.066

 Histology

  Non-AD

1

1

  AD

1.37 (0.70–2.66)

0.352

1.71 (0.93–3.15)

0.183

 Tumor differentiation

  Well/moderate

1

1

  Poor

1.58 (0.80–3.12)

0.187

1.14 (0.61–2.14)

0.677

 Naive CD4+

  Low

1

1

  High

0.35 (0.17–0.70)

0.001

0.60 (0.32–1.12)

0.09

 Memory CD4+

  Low

1

1

  High

1.51 (0.76–2.98)

0.223

1.36 (0.73–2.51)

0.298

 Naive CD8+

  Low

1

1

  High

0.72 (0.36–1.41)

0.335

0.54 (0.29–1.01)

0.037

 Memory CD8+

  Low

1

1

  High

1.24 (0.63–2.44)

0.519

1.50 (0.81–2.77)

0.175

 CD4+ naive/memory

  Low

1

1

  High

0.48 (0.24–0.97)

0.03

0.78 (0.42–1.44)

0.411

 CD8+ naive/memory

  Low

1

1

  High

0.69 (0.35–1.36)

0.279

0.53 (0.28–0.99)

0.032

 Naive CD8/CD4

  Low

1

1

  High

1.26 (0.64–2.47)

0.491

0.89 (0.48–1.63)

0.708

 Memory CD8/CD4

  Low

1

1

 High

1.35 (0.68–2.64)

0.377

1.56 (0.84–2.87)

0.133

Multivariate analysis

 Naive CD4+

  Low

1

1

  High

0.11 (0.02–0.55)

0.007

0.73 (0.35–1.52)

0.400

 CD4+ naive/memory

  Low

1

–

  High

3.63 (0.77–16.95)

0.101

–

–

 Naive CD8+

  Low

–

1

  High

–

–

0.69 (0.11–4.17)

0.693

 CD8+ naive/memory

  Low

–

1

  High

–

–

0.80 (0.12–5.03)

0.815

 cStage

  III

–

1

  IV

–

–

1.97 (0.99–3.92)

0.051