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Table 3 Cox regression analysis of survival for never smokers among NSCLC patients

From: Smoking history influences the prognostic value of peripheral naïve CD4+ T cells in advanced non-small cell lung cancer

Variables

OS

PFS

HR (95% CI)

P value

HR (95% CI)

P value

Univariate analysis

 Age (years)

  < 60

1

 

1

 

  ≥ 60

0.46 (0.19–1.09)

0.081

0.44 (0.21–0.95)

0.036

 Gender

  Female

1

 

1

 

  Male

1.81 (0.76–4.32)

0.18

2.06 (0.94–4.52)

0.07

 Performance status

  0

1

 

1

 

  1–2

1.36 (0.39–4.70)

0.625

1.32 (0.50–3.50)

0.568

 cStage

  III

1

 

1

 

  IV

0.98 (0.36–1.70)

0.981

0.73 (0.32–1.65)

0.451

 Histology

  Non-AD

1

 

1

 

  AD

0.87 (0.35–3.15)

0.77

0.81 (0.36–1.79)

0.61

 Tumor differentiation

  Well/moderate

1

 

1

 

  Poor

1.86 (0.76–4.50)

0.169

2.74 (1.22–6.14)

0.014

 Naive CD4+

  Low

1

 

1

 

  High

3.19 (1.38–7.40)

0.009

2.07 (0.97–4.41)

0.062

 Memory CD4+

  Low

1

 

1

 

  High

0.92 (0.40–2.13)

0.855

0.75 (0.35–1.61)

0.47

 Naive CD8+

  Low

1

 

1

 

  High

1.61 (0.69–3.72)

0.273

1.70 (0.79–3.62)

0.165

 Memory CD8+

  Low

1

 

1

 

  High

0.76 (0.33–1.77)

0.536

0.77 (0.36–1.65)

0.509

 CD4+ naive/memory

  Low

1

 

1

 

  High

1.77 (0.76–4.08)

0.187

2.07 (0.97–4.42)

0.056

 CD8+ naive/memory

  Low

1

 

1

 

  High

1.29 (0.56–2.99)

0.544

1.33 (0.62–2.83)

0.455

 Naive CD8/CD4

  Low

1

 

1

 

  High

1.16 (0.50–2.70)

0.706

0.98 (0.46–2.09)

0.964

 Memory CD8/CD4

  Low

1

 

1

 

  High

0.72 (0.31–1.68)

0.451

0.62 (0.29–1.33)

0.214

Multivariate analysis

 Naive CD4+

  Low

1

 

1

 

  High

2.17 (1.15–5.49)

0.012

2.43 (0.22–26.80)

0.468

 CD4+ naive/memory

  Low

   

  High

0.82 (0.09–7.18)

0.858

 Age (years)

  < 60

1

 

1

 

  ≥ 60

0.47 (0.19–1.13)

0.094

0.70 (0.28–1.74)

0.447

 Gender

  Female

 

1

 

  Male

1.79 (0.72–4.48)

0.209

 Tumor differentiation

  Well/moderate

 

1

 

  Poor

2.07 (0.84–5.08)

0.112