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Table 3 Cox regression analysis of survival for never smokers among NSCLC patients

From: Smoking history influences the prognostic value of peripheral naïve CD4+ T cells in advanced non-small cell lung cancer

Variables OS PFS
HR (95% CI) P value HR (95% CI) P value
Univariate analysis
 Age (years)
  < 60 1   1  
  ≥ 60 0.46 (0.19–1.09) 0.081 0.44 (0.21–0.95) 0.036
 Gender
  Female 1   1  
  Male 1.81 (0.76–4.32) 0.18 2.06 (0.94–4.52) 0.07
 Performance status
  0 1   1  
  1–2 1.36 (0.39–4.70) 0.625 1.32 (0.50–3.50) 0.568
 cStage
  III 1   1  
  IV 0.98 (0.36–1.70) 0.981 0.73 (0.32–1.65) 0.451
 Histology
  Non-AD 1   1  
  AD 0.87 (0.35–3.15) 0.77 0.81 (0.36–1.79) 0.61
 Tumor differentiation
  Well/moderate 1   1  
  Poor 1.86 (0.76–4.50) 0.169 2.74 (1.22–6.14) 0.014
 Naive CD4+
  Low 1   1  
  High 3.19 (1.38–7.40) 0.009 2.07 (0.97–4.41) 0.062
 Memory CD4+
  Low 1   1  
  High 0.92 (0.40–2.13) 0.855 0.75 (0.35–1.61) 0.47
 Naive CD8+
  Low 1   1  
  High 1.61 (0.69–3.72) 0.273 1.70 (0.79–3.62) 0.165
 Memory CD8+
  Low 1   1  
  High 0.76 (0.33–1.77) 0.536 0.77 (0.36–1.65) 0.509
 CD4+ naive/memory
  Low 1   1  
  High 1.77 (0.76–4.08) 0.187 2.07 (0.97–4.42) 0.056
 CD8+ naive/memory
  Low 1   1  
  High 1.29 (0.56–2.99) 0.544 1.33 (0.62–2.83) 0.455
 Naive CD8/CD4
  Low 1   1  
  High 1.16 (0.50–2.70) 0.706 0.98 (0.46–2.09) 0.964
 Memory CD8/CD4
  Low 1   1  
  High 0.72 (0.31–1.68) 0.451 0.62 (0.29–1.33) 0.214
Multivariate analysis
 Naive CD4+
  Low 1   1  
  High 2.17 (1.15–5.49) 0.012 2.43 (0.22–26.80) 0.468
 CD4+ naive/memory
  Low    
  High 0.82 (0.09–7.18) 0.858
 Age (years)
  < 60 1   1  
  ≥ 60 0.47 (0.19–1.13) 0.094 0.70 (0.28–1.74) 0.447
 Gender
  Female   1  
  Male 1.79 (0.72–4.48) 0.209
 Tumor differentiation
  Well/moderate   1  
  Poor 2.07 (0.84–5.08) 0.112