Fig. 2

Inhibition of MCT1 renders a metabolic-switch phenotype. MCF7 cells were treated with SR13800 at 0, 10 or 20 nM for 48 h, the (a) glucose uptake, (b) lactate production, (c) OCR, (d) cellular ATP/ADP ratio, (e) intracellular lactate and (f) extracellular lactate were measured. g MCF7 cells were transfected with control siRNA or siMCT1 for 48 h, the glucose uptake, (h) lactate production, (i) OCR, (j) cellular ATP/ADP ratio, (k) intracellular lactate and (l) extracellular lactate were measured. *p < 0.05; **p < 0.01; ***p < 0.001